Resistance to what, does it matter? How do we study it?

Resistance to what, does it matter? How do we study it?

The importance of platelets and thrombosis in the pathophysiology of acute ischaemic coronary syndromes has been well appreciated. This information has formed the backbone of the guidelines on both sides of the Atlantic that patients with acute as well as chronic coronary artery disease be treated with aspirin as a longterm strategy of care. While the specific dosage schedule may vary, aspirin ...

What Does It Mean and How Do We Measure It?

T he paper by Bonow et al' in this issue of Circulation reports important empirical observations on measuring myocardial viability in humans with the potassium analogue thallium-201. After obtaining standard 20'1f exercise and redistribution images, a second dose of 201TI was injected and a third (reinjection) image was obtained beginning 10-15 minutes later. The reinjection images identified v...

Macroeconomic uncertainty : what is it , how can we measure it and why does it matter ?

Since mid-2008, the UK economy has faced an unprecedented series of large adverse shocks that have led companies and households to become more uncertain about future economic prospects. These shocks include one of the United Kingdom’s largest ever financial crises, continuing headwinds from the euro-area debt crisis and the implementation of the Government’s fiscal consolidation programme. The ...

What Do We Know, How Do We Know It, and How Can We Best Apply It?

Adequate Nutrition May get You Home: Effect of Caloric/Protein Deficits on the Discharge Destination of Critically Ill Surgical Patients 37 D. Dante Yeh, MD; Eva Fuentes, MD; Sadeq A. Quraishi, MD, MHA, MMScH; Catrina Cropano, MSc; Haytham Kaafarani, MD, MPH; Jarone Lee, MD, MPH; David R. King, MD; Marc DeMoya, MD; Peter Fagenholz, MD; Kathryn Butler, MD; Yuchiao Chang, PhD; and George Velmahos...

Evolvability: What Is It and How Do We Get It?